CD300C Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CD300C.
|Calculated MW||24830 Da|
|Other Names||CMRF35-like molecule 6, CLM-6, CD300 antigen-like family member C, CMRF35-A1, CMRF-35, Immunoglobulin superfamily member 16, IgSF16, CD300c, CD300C, CMRF35, CMRF35A, CMRF35A1, IGSF16|
|Target/Specificity||CD300C (NP_006669, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CD300C Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).
The CD300 molecules regulate monocyte and dendritic cell functions. Clark GJ, et al. Immunobiology, 2009. PMID 19592130.The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions. Clark GJ, et al. Trends Immunol, 2009 May. PMID 19359216.CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands. Ju X, et al. Blood, 2008 Aug 15. PMID 18535206.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
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