CHD4 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CHD4.
|Application ||WB, IHC, E|
|Calculated MW||218005 Da|
|Other Names||Chromodomain-helicase-DNA-binding protein 4, CHD-4, ATP-dependent helicase CHD4, Mi-2 autoantigen 218 kDa protein, Mi2-beta, CHD4|
|Target/Specificity||CHD4 (NP_001264, 1632 a.a. ~ 1730 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CHD4 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. Li R, et al. EMBO J, 2009 Sep 16. PMID 19644445.Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications. Musselman CA, et al. Biochem J, 2009 Sep 25. PMID 19624289.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.The Mi-2/NuRD complex associates with pericentromeric heterochromatin during S phase in rapidly proliferating lymphoid cells. Helbling Chadwick L, et al. Chromosoma, 2009 Aug. PMID 19296121.Mi2beta shows chromatin enzyme specificity by erasing a DNase I-hypersensitive site established by ACF. Ishii H, et al. J Biol Chem, 2009 Mar 20. PMID 19158090.
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