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CLCN2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CLCN2.
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P51788 |
| Other Accession | BC021578 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 30 |
| Calculated MW | 98535 Da |
| Gene ID | 1181 |
|---|---|
| Other Names | Chloride channel protein 2, ClC-2, CLCN2 |
| Target/Specificity | CLCN2 (AAH21578.1, 38 a.a. ~ 387 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CLCN2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
Provided below are standard protocols that you may find useful for product applications.
Background
The transmembrane protein encoded by this gene is a voltage-gated chloride channel that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.
References
Analysis of CLCN2 as candidate gene for megalencephalic leukoencephalopathy with subcortical cysts. Scheper GC, et al. Genet Test Mol Biomarkers, 2010 Apr. PMID 20187760. Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. Cornejo I, et al. J Cell Physiol, 2009 Dec. PMID 19711355. CLCN2 variants in idiopathic generalized epilepsy. Kleefuss-Lie A, et al. Nat Genet, 2009 Sep. PMID 19710712. Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. Thompson CH, et al. J Biol Chem, 2009 Sep 18. PMID 19574231. PIKfyve-dependent regulation of the Cl- channel ClC-2. Klaus F, et al. Biochem Biophys Res Commun, 2009 Apr 10. PMID 19232516.
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