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COG7 Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT1580a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
COG7 Antibody (monoclonal) (M01) - Product info | |
| Application | IF, WB
|
| Primary Accession | P83436 |
| Reactivity | Human |
| Isotype | IgG1 kappa |
| Clone Names | 3G4-1B3 |
| Calculated MW | 86344 Da |
COG7 Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 91949 | |
| Other Names CDG2Ecomponent of oligomeric golgi complex 7 | |
| Target/Specificity COG7 (AAH37563, 1 a.a. ~ 771 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions COG7 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
COG7 Antibody (monoclonal) (M01) - Related products
COG7 Antibody (monoclonal) (M01) - Application data
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Immunofluorescence of monoclonal antibody to COG7 (AT1580a) on HeLa cell. [antibody concentration 10ug/ml]
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Western Blot analysis of COG7 expression in transfected 293T cell line by COG7 monoclonal antibody (M01), clone 3G4-1B3.
Lane 1: COG7 transfected lysate(65 KDa).
Lane 2: Non-transfected lysate.
COG7 Antibody (monoclonal) (M01) - Research Areas
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BACKGROUND
The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.
REFERENCES
A new mutation in COG7 extends the spectrum of COG subunit deficiencies. Zeevaert R, et al. Eur J Med Genet, 2009 Sep-Oct. PMID 19577670.Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. Laufman O, et al. EMBO J, 2009 Jul 22. PMID 19536132.A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia. Morava E, et al. Eur J Hum Genet, 2007 Jun. PMID 17356545.COG-7-deficient Human Fibroblasts Exhibit Altered Recycling of Golgi Proteins. Steet R, et al. Mol Biol Cell, 2006 May. PMID 16510524.COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation. Shestakova A, et al. Traffic, 2006 Feb. PMID 16420527.
