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CRYBB1 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant CRYBB1.

  • WB - CRYBB1 Antibody (monoclonal) (M01) AT1642a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (53.46 KDa) .
  • E - CRYBB1 Antibody (monoclonal) (M01) AT1642a
    Detection limit for recombinant GST tagged CRYBB1 is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P53674
Other Accession BC036790
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 2B2
Calculated MW 28023 Da
Additional Information
Gene ID 1414
Other Names Beta-crystallin B1, Beta-B1 crystallin, CRYBB1
Target/Specificity CRYBB1 (AAH36790.1, 1 a.a. ~ 252 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCRYBB1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3.


Truncated human betaB1-crystallin shows altered structural properties and interaction with human betaA3-crystallin. Srivastava K, et al. Biochemistry, 2009 Aug 4. PMID 19548648.Lens aging: effects of crystallins. Sharma KK, et al. Biochim Biophys Acta, 2009 Oct. PMID 19463898.Initiation codon mutation in betaB1-crystallin (CRYBB1) associated with autosomal recessive nuclear pulverulent cataract. Meyer E, et al. Mol Vis, 2009 May 18. PMID 19461930.Deamidation alters interactions of beta-crystallins in hetero-oligomers. Takata T, et al. Mol Vis, 2009. PMID 19190732.Disulfide cross-links in the interaction of a cataract-linked alphaA-crystallin mutant with betaB1-crystallin. Kumar MS, et al. FEBS Lett, 2009 Jan 5. PMID 19071118.

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$ 315.00
Cat# AT1642a
(40 western blots)
Availability: 7-10 days
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