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CSE1L Antibody (monoclonal) (M03)

Mouse monoclonal antibody raised against a partial recombinant CSE1L.

  • WB - CSE1L Antibody (monoclonal) (M03) AT1652a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • WB - CSE1L Antibody (monoclonal) (M03) AT1652a
    CSE1L monoclonal antibody (M03), clone 2C10 Western Blot analysis of CSE1L expression in MCF-7 ( (Cat # AT1652a )
  • IHC - CSE1L Antibody (monoclonal) (M03) AT1652a
    Immunoperoxidase of monoclonal antibody to CSE1L on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml]
  • IF - CSE1L Antibody (monoclonal) (M03) AT1652a
    Immunofluorescence of monoclonal antibody to CSE1L on HeLa cell. [antibody concentration 10 ug/ml]
  • E - CSE1L Antibody (monoclonal) (M03) AT1652a
    Detection limit for recombinant GST tagged CSE1L is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P55060
Other Accession NM_001316
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 kappa
Clone Names 2C10
Calculated MW 110417 Da
Additional Information
Gene ID 1434
Other Names Exportin-2, Exp2, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter, CSE1L, CAS, XPO2
Target/Specificity CSE1L (NP_001307, 872 a.a. ~ 971 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCSE1L Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.


Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.Function of CSE1L/CAS in the secretion of HT-29 human colorectal cells and its expression in human colon. Tsao TY, et al. Mol Cell Biochem, 2009 Jul. PMID 19224336.PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. Kim HE, et al. Mol Cell, 2008 Apr 25. PMID 18439902.Dissection of the molecular mechanisms that control the nuclear accumulation of transport factors importin-alpha and CAS in stressed cells. Kodiha M, et al. Cell Mol Life Sci, 2008 Jun. PMID 18425415.CSE1L/CAS, a microtubule-associated protein, inhibits taxol (paclitaxel)-induced apoptosis but enhances cancer cell apoptosis induced by various chemotherapeutic drugs. Liao CF, et al. BMB Rep, 2008 Mar 31. PMID 18377724.

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$ 315.00
Cat# AT1652a
(40 western blots)
Availability: 7-10 days
Bulk Size
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