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CTH Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full length recombinant CTH.
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Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (70.07 KDa) .
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CTH monoclonal antibody (M03), clone S51. Western Blot analysis of CTH expression in mouse kidney.
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CTH monoclonal antibody (M03), clone S51 Western Blot analysis of CTH expression in K-562 ( (Cat # AT1668a )
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Western Blot analysis of CTH expression in transfected 293T cell line by CTH monoclonal antibody (M03), clone S51.
Lane 1: CTH transfected lysate(45 KDa).
Lane 2: Non-transfected lysate.
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Immunoperoxidase of monoclonal antibody to CTH on formalin-fixed paraffin-embedded human pancreas. [antibody concentration 3 ug/ml]
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Detection limit for recombinant GST tagged CTH is approximately 1ng/ml as a capture antibody.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P32929 |
| Other Accession | BC015807 |
| Reactivity | Human, Mouse |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | S51 |
| Calculated MW | 44508 Da |
| Gene ID | 1491 |
|---|---|
| Other Names | Cystathionine gamma-lyase, Cysteine-protein sulfhydrase, Gamma-cystathionase, CTH |
| Target/Specificity | CTH (AAH15807, 1 a.a. ~ 405 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CTH Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
References
1.cGMP-Dependent Protein Kinase Contributes to Hydrogen Sulfide-Stimulated Vasorelaxation.Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Zaid A, Giannogonas P, Cantalupo A, Dhayade S, Karalis KP, Wang R, Feil R, Cirino G.PLoS One. 2012;7(12):e53319. doi: 10.1371/journal.pone.0053319. Epub 2012 Dec 28.2.Hydrogen sulfide impairs glucose utilization and increases gluconeogenesis in hepatocytes.Zhang L, Yang G, Untereiner A, Ju Y, Wu L, Wang R.Endocrinology. 2013 Jan;154(1):114-26. doi: 10.1210/en.2012-1658. Epub 2012 Nov 26.3.An investigation of the mechanisms of hydrogen sulfide-induced vasorelaxation in rat middle cerebral arteries.Streeter E, Hart J, Badoer E.Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul 17.4.Characterization of Hydrogen Sulfide and Its Synthases, Cystathionine ?]-Synthase and Cystathionine ?^-Lyase, in Human Prostatic Tissue and Cells.Guo H, Gai JW, Wang Y, Jin HF, Du JB, Jin J.Urology. 2012 Feb;79(2):483.e1-5.5.Glucocorticoids suppress cystathionine gamma-lyase expression and H(2)S production in lipopolysaccharide-treated macrophages.Zhu XY, Liu SJ, Liu YJ, Wang S, Ni X.Cell Mol Life Sci. 2010 Jan 10. [Epub ahead of print]6.H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of KATP channels.Siebert N, Cantre D, Eipel C, Vollmar B.Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1266-73. Epub 2008 Oct 30.
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