DNAI1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant DNAI1.
|Calculated MW||79283 Da|
|Other Names||Dynein intermediate chain 1, axonemal, Axonemal dynein intermediate chain 1, DNAI1|
|Target/Specificity||DNAI1 (AAH30583, 1 a.a. ~ 699 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||DNAI1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Primary ciliary dyskinesia: improving the diagnostic approach. Leigh MW, et al. Curr Opin Pediatr, 2009 Jun. PMID 19300264.Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia. Zuccarello D, et al. Hum Reprod, 2008 Aug. PMID 18492703.DNAI1 mutations explain only 2% of primary ciliary dykinesia. Failly M, et al. Respiration, 2008. PMID 18434704.Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation. Zariwala MA, et al. Am J Respir Crit Care Med, 2006 Oct 15. PMID 16858015.
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