DNM1L Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant DNM1L.
|Application ||WB, IHC, E|
|Calculated MW||81877 Da|
|Other Names||Dynamin-1-like protein, Dnm1p/Vps1p-like protein, DVLP, Dynamin family member proline-rich carboxyl-terminal domain less, Dymple, Dynamin-like protein, Dynamin-like protein 4, Dynamin-like protein IV, HdynIV, Dynamin-related protein 1, DNM1L, DLP1, DRP1|
|Target/Specificity||DNM1L (AAH24590.1, 1 a.a. ~ 710 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||DNM1L Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.
1.Hyperinsulinemia induces insulin resistance in dorsal root ganglion neurons.Kim B, McLean LL, Philip SS, Feldman EL.Endocrinology. 2011 Oct;152(10):3638-47. Epub 2011 Aug 2.2.Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy.Vincent AM, Edwards JL, McLean LL, Hong Y, Cerri F, Lopez I, Quattrini A, Feldman EL.Acta Neuropathol. 2010 May 15. [Epub ahead of print]3.Diabetes regulates mitochondrial biogenesis and fission in mouse neurons.Edwards JL, Quattrini A, Lentz SI, Figueroa-Romero C, Cerri F, Backus C, Hong Y, Feldman EL.Diabetologia. 2009 Oct 22. [Epub ahead of print]4.SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle.Figueroa-Romero C, Iniguez-Lluh JA, Stadler J, Chang CR, Arnoult D, Keller PJ, Hong Y, Blackstone C, Feldman EL.FASEB J. 2009 Jul 28. [Epub ahead of print]
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