DNMT2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant DNMT2.
|Application ||WB, IF|
|Calculated MW||44597 Da|
|Other Names||tRNA (cytosine(38)-C(5))-methyltransferase, DNA (cytosine-5)-methyltransferase-like protein 2, Dnmt2, DNA methyltransferase homolog HsaIIP, DNA MTase homolog HsaIIP, MHsaIIP, PuMet, TRDMT1, DNMT2|
|Target/Specificity||DNMT2 (AAH47733, 1 a.a. ~ 391 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||DNMT2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa.
Hepatitis B virus replication induces methylation of both host and viral DNA. Vivekanandan P, et al. J Virol, 2010 May. PMID 20147412.Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. Oguri M, et al. Am J Hypertens, 2010 Jan. PMID 19851296.Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines. Schaefer M, et al. Cancer Res, 2009 Oct 15. PMID 19808971.Genetic variation in healthy oldest-old. Halaschek-Wiener J, et al. PLoS One, 2009 Aug 14. PMID 19680556.A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation. El-Maarri O, et al. Hum Mol Genet, 2009 May 15. PMID 19246518.
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