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>   home   >   Products   >   Primary Antibodies   >   DPYS Antibody (monoclonal) (M01)   

DPYS Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant DPYS.

  • E - DPYS Antibody (monoclonal) (M01) AT1816a
    Detection limit for recombinant GST tagged DPYS is approximately 0.1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14117
Other Accession NM_001385
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 3B1
Calculated MW 56630 Da
Additional Information
Gene ID 1807
Other Names Dihydropyrimidinase, DHP, DHPase, Dihydropyrimidine amidohydrolase, Hydantoinase, DPYS
Target/Specificity DPYS (NP_001376, 422 a.a. ~ 519 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsDPYS Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.


Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT. Kim HY, et al. BMB Rep, 2010 Aug. PMID 20797317.Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients. van Kuilenburg AB, et al. Biochim Biophys Acta, 2010 Jul-Aug. PMID 20362666.Contribution of dihydropyrimidinase gene alterations to the development of serious toxicity in fluoropyrimidine-treated cancer patients. Fidlerova J, et al. Cancer Chemother Pharmacol, 2010 Mar. PMID 19649633.Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism. Thomas HR, et al. Pharmacogenet Genomics, 2008 Jan. PMID 18216719.Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism. Thomas HR, et al. Pharmacogenet Genomics, 2007 Nov. PMID 18075467.

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$ 315.00
Cat# AT1816a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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