E2F3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant E2F3.
|Application ||WB, E|
|Calculated MW||49162 Da|
|Other Names||Transcription factor E2F3, E2F-3, E2F3, KIAA0075|
|Target/Specificity||E2F3 (NP_001940, 336 a.a. ~ 425 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||E2F3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.
Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds. Biswas S, et al. Proc Natl Acad Sci U S A, 2010 Apr 13. PMID 20308562.E2F3 is a mediator of DNA damage-induced apoptosis. Martinez LA, et al. Mol Cell Biol, 2010 Jan. PMID 19917728.Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. Cunningham JM, et al. Br J Cancer, 2009 Oct 20. PMID 19738611.KIF14 and E2F3 mRNA expression in human retinoblastoma and its phenotype association. Madhavan J, et al. Mol Vis, 2009. PMID 19190782.MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a. Zhang Y, et al. J Mol Med, 2009 Jan. PMID 18810376.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.