E2F3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant E2F3.
|Application ||WB, E|
|Calculated MW||49162 Da|
|Other Names||Transcription factor E2F3, E2F-3, E2F3, KIAA0075|
|Target/Specificity||E2F3 (NP_001940, 336 a.a. ~ 425 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||E2F3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.
Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds. Biswas S, et al. Proc Natl Acad Sci U S A, 2010 Apr 13. PMID 20308562.E2F3 is a mediator of DNA damage-induced apoptosis. Martinez LA, et al. Mol Cell Biol, 2010 Jan. PMID 19917728.Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. Cunningham JM, et al. Br J Cancer, 2009 Oct 20. PMID 19738611.KIF14 and E2F3 mRNA expression in human retinoblastoma and its phenotype association. Madhavan J, et al. Mol Vis, 2009. PMID 19190782.MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a. Zhang Y, et al. J Mol Med, 2009 Jan. PMID 18810376.
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