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EIF4G2 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant EIF4G2.

  • WB - EIF4G2 Antibody (monoclonal) (M01) AT1882a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (34.43 KDa) .
  • WB - EIF4G2 Antibody (monoclonal) (M01) AT1882a
    EIF4G2 monoclonal antibody (M01), clone 3B5. Western Blot analysis of EIF4G2 expression in PC-12 ( (Cat # AT1882a )
  • WB - EIF4G2 Antibody (monoclonal) (M01) AT1882a
    EIF4G2 monoclonal antibody (M01), clone 3B5 Western Blot analysis of EIF4G2 expression in Hela S3 NE ( (Cat # AT1882a )
  • IHC - EIF4G2 Antibody (monoclonal) (M01) AT1882a
    Immunoperoxidase of monoclonal antibody to EIF4G2 on formalin-fixed paraffin-embedded human heart. [antibody concentration 3 ug/ml]
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78344
Other Accession NM_001418
Reactivity Human, Rat
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 3B5
Calculated MW 102362 Da
Additional Information
Gene ID 1982
Other Names Eukaryotic translation initiation factor 4 gamma 2, eIF-4-gamma 2, eIF-4G 2, eIF4G 2, Death-associated protein 5, DAP-5, p97, EIF4G2 (HGNC:3297)
Target/Specificity EIF4G2 (NP_001409, 811 a.a. ~ 889 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsEIF4G2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.


Crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5. Frank F, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Jan 1. PMID 20057060.Translation of mRNAs from vesicular stomatitis virus and vaccinia virus is differentially blocked in cells with depletion of eIF4GI and/or eIF4GII. Welnowska E, et al. J Mol Biol, 2009 Dec 4. PMID 19769989.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.The crystal structure of the C-terminal DAP5/p97 domain sheds light on the molecular basis for its processing by caspase cleavage. Liberman N, et al. J Mol Biol, 2008 Nov 14. PMID 18722383.Death-associated protein 5 (DAP5/p97/NAT1) contributes to retinoic acid-induced granulocytic differentiation and arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Ozpolat B, et al. Apoptosis, 2008 Jul. PMID 18491231.

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$ 315.00
Cat# AT1882a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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