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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   F11 monoclonal antibody (M01), clone 2H8   

F11 monoclonal antibody (M01), clone 2H8

Purified Mouse Monoclonal Antibody (Mab)

     
  • WB - F11 monoclonal antibody (M01), clone 2H8 AT1973a
    Western Blot detection against Immunogen (36.74 KDa) .
  • WB - F11 monoclonal antibody (M01), clone 2H8 AT1973a
    Western Blot analysis of F11 expression in transfected 293T cell line by F11 monoclonal antibody (M01), clone 2H8. Lane 1: F11 transfected lysate(70.1 KDa). Lane 2: Non-transfected lysate.
  • WB - F11 monoclonal antibody (M01), clone 2H8 AT1973a
    Immunoprecipitation of F11 transfected lysate using anti-F11 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with F11 MaxPab rabbit polyclonal antibody.
  • E - F11 monoclonal antibody (M01), clone 2H8 AT1973a
    Detection limit for recombinant GST tagged F11 is approximately 10ng/ml as a capture antibody.
  •  - F11 monoclonal antibody (M01), clone 2H8 AT1973a
    Detection limit for recombinant GST tagged F11 is approximately 10ng/ml as a capture antibody.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E, IP
Primary Accession P03951
Other Accession NP_000119
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 2H8
Calculated MW 70109 Da
Additional Information
Gene ID 2160
Other Names Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain, F11
Target/Specificity F11 (NP_000119, 286 a.a. ~ 385 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsF11 monoclonal antibody (M01), clone 2H8 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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Background

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.

References

Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Association of common genetic variations and idiopathic venous thromboembolism. Results from EDITh, a hospital-based case-control study. Delluc A, et al. Thromb Haemost, 2010 Jun. PMID 20352152.Gene variants associated with venous thrombosis: confirmation in the MEGA study. Arellano AR, et al. J Thromb Haemost, 2010 May. PMID 20128871.Structure and function of factor XI. Emsley J, et al. Blood, 2010 Apr 1. PMID 20110423.Molecular characterization of in-frame and out-of-frame alternative splicings in coagulation factor XI pre-mRNA. Asselta R, et al. Blood, 2010 Mar 11. PMID 20042724.

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$ 315.00
Cat# AT1973a
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