|Application ||WB, IP, E|
|Calculated MW||70037 Da|
|Other Names||Prothrombin, Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain, F2|
|Target/Specificity||F2 (AAH51332, 263 a.a. ~ 362 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||F2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
The association of protein S Tokushima-K196E with a risk of deep vein thrombosis. Ikejiri M, et al. Int J Hematol, 2010 Sep. PMID 20811787.Role of Genetic and Acquired Prothrombotic Risk Factors in Genesis of Sudden Sensorineural Hearing Loss. Fusconi M, et al. Audiol Neurootol, 2010 Aug 25. PMID 20798492.Risk of venous thrombosis in pregnancy among carriers of the factor V Leiden and the prothrombin gene G20210A polymorphisms. Jacobsen AF, et al. J Thromb Haemost, 2010 Aug 23. PMID 20735725.Prothrombotic state, cardiovascular and metabolic syndrome risk factors in prepubertal children born large-for-gestational age (LGA). Evagelidou EN, et al. Diabetes Care, 2010 Aug 19. PMID 20724652.Thrombophilic risk factors for placental stillbirth. Simchen MJ, et al. Eur J Obstet Gynecol Reprod Biol, 2010 Aug 11. PMID 20708329.
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