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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FADD Antibody (monoclonal) (M01)   

FADD Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant FADD.

  • WB - FADD Antibody (monoclonal) (M01) AT1988a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
  • WB - FADD Antibody (monoclonal) (M01) AT1988a
    FADD monoclonal antibody (M01), clone 3A12 Western Blot analysis of FADD expression in A-431 ( (Cat # AT1988a )
  • E - FADD Antibody (monoclonal) (M01) AT1988a
    Detection limit for recombinant GST tagged FADD is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13158
Other Accession BC000334
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 lambda
Clone Names 3A12
Calculated MW 23279 Da
Additional Information
Gene ID 8772
Other Names FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1
Target/Specificity FADD (AAH00334, 109 a.a. ~ 208 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsFADD Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.


Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308.Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4. Li P, et al. J Biol Chem, 2010 Jul 16. PMID 20484047.Lack of Fas-pathway gene mutations in primary resected esophageal squamous cell carcinoma. Ko CL, et al. Chang Gung Med J, 2010 Mar-Apr. PMID 20438666.Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR). von Roretz C, et al. J Biol Chem, 2010 May 28. PMID 20353946.Localization of the death effector domain of Fas-associated death domain protein into the membrane of Escherichia coli induces reactive oxygen species-involved cell death. Thorenoor N, et al. Biochemistry, 2010 Feb 23. PMID 20070122.

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$ 315.00
Cat# AT1988a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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