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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   FH Antibody (monoclonal) (M09)   

FH Antibody (monoclonal) (M09)

Mouse monoclonal antibody raised against a full length recombinant FH.

  • WB - FH Antibody (monoclonal) (M09) AT2045a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (78.32 KDa) .
  • WB - FH Antibody (monoclonal) (M09) AT2045a
    FH monoclonal antibody (M09), clone 3E7 Western Blot analysis of FH expression in HeLa ( (Cat # AT2045a )
  • IHC - FH Antibody (monoclonal) (M09) AT2045a
    Immunoperoxidase of monoclonal antibody to FH on formalin-fixed paraffin-embedded human seminoma. [antibody concentration 3 ug/ml]
  • E - FH Antibody (monoclonal) (M09) AT2045a
    Detection limit for recombinant GST tagged FH is 0.3 ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07954
Other Accession BC003108
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2b Kappa
Clone Names 3E8
Calculated MW 54637 Da
Additional Information
Gene ID 2271
Other Names Fumarate hydratase, mitochondrial, Fumarase, FH
Target/Specificity FH (AAH03108, 33 a.a. ~ 510 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsFH Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.


An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response. Yogev O, et al. PLoS Biol, 2010 Mar 9. PMID 20231875.UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. Yang Y, et al. Cancer Genet Cytogenet, 2010 Jan 1. PMID 19963135.Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. McCauley JL, et al. Genes Immun, 2009 Oct. PMID 19626040.Novel role of fumarate metabolism in dahl-salt sensitive hypertension. Tian Z, et al. Hypertension, 2009 Aug. PMID 19546378.

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$ 315.00
Cat# AT2045a
(40 western blots)
Availability: 7-10 days
Bulk Size
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