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FKBP1B Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant FKBP1B.

  • WB - FKBP1B Antibody (monoclonal) (M01) AT2056a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (34.54 KDa) .
  • WB - FKBP1B Antibody (monoclonal) (M01) AT2056a
    Western Blot analysis of FKBP1B expression in transfected 293T cell line by FKBP1B monoclonal antibody (M01), clone 4H5-1B6.

    Lane 1: FKBP1B transfected lysate(11.8 KDa).
    Lane 2: Non-transfected lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P68106
Other Accession BC002614
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 kappa
Clone Names 4H5-1B6
Calculated MW 11783 Da
Additional Information
Gene ID 2281
Other Names Peptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 126 kDa FK506-binding protein, 126 kDa FKBP, FKBP-126, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP126, Rotamase, h-FKBP-12, FKBP1B, FKBP126, FKBP1L, FKBP9, OTK4
Target/Specificity FKBP1B (AAH02614, 1 a.a. ~ 80 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsFKBP1B Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.


Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Guo T, et al. Circ Res, 2010 Jun 11. PMID 20431056.Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer. Cornea RL, et al. J Biol Chem, 2010 Jun 18. PMID 20404344.FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. Zissimopoulos S, et al. Biochem J, 2009 Apr 15. PMID 19226252.Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. Lowe JK, et al. PLoS Genet, 2009 Feb. PMID 19197348.Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. Xiao J, et al. J Biol Chem, 2007 Nov 30. PMID 17921453.

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$ 315.00
Cat# AT2056a
(40 western blots)
Availability: 7-10 days
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