FLI1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a full length recombinant FLI1.
|Application ||WB, IF|
|Calculated MW||50982 Da|
|Other Names||Friend leukemia integration 1 transcription factor, Proto-oncogene Fli-1, Transcription factor ERGB, FLI1|
|Target/Specificity||FLI1 (AAH01670, 1 a.a. ~ 452 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||FLI1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells. Riggi N, et al. Genes Dev, 2010 May. PMID 20382729.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial. Le Deley MC, et al. J Clin Oncol, 2010 Apr 20. PMID 20308673.Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group. van Doorninck JA, et al. J Clin Oncol, 2010 Apr 20. PMID 20308669.EWS/FLI1 oncogene activates caspase 3 transcription and triggers apoptosis in vivo. Sohn EJ, et al. Cancer Res, 2010 Feb 1. PMID 20103643.
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