FST Antibody (monoclonal) (M01A)
Mouse monoclonal antibody raised against a full-length recombinant FST.
|Calculated MW||38007 Da|
|Other Names||Follistatin, FS, Activin-binding protein, FST|
|Target/Specificity||FST (AAH04107, 1 a.a. ~ 344 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||FST Antibody (monoclonal) (M01A) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.Increased follistatin levels after oral contraceptive treatment in obese and non-obese women with polycystic ovary syndrome. Chen MJ, et al. Hum Reprod, 2010 Mar. PMID 20093255.Differential expression of follistatin and FLRG in human breast proliferative disorders. Bloise E, et al. BMC Cancer, 2009 Sep 9. PMID 19740438.Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study. Fajardo M, et al. Clin Orthop Relat Res, 2009 Dec. PMID 19597895.
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