FTS Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant FTS.
|Calculated MW||33128 Da|
|Other Names||AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS|
|Target/Specificity||FTS (AAH01134, 1 a.a. ~ 292 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||FTS Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer. Notaridou M, et al. Int J Cancer, 2010 Jul 15. PMID 20635389.Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival. Quaye L, et al. Hum Mol Genet, 2009 May 15. PMID 19270026.An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Xu L, et al. Mol Biol Cell, 2008 Dec. PMID 18799622.Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
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