FUBP1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full-length recombinant FUBP1.
|Application ||WB, E|
|Calculated MW||67560 Da|
|Other Names||Far upstream element-binding protein 1, FBP, FUSE-binding protein 1, DNA helicase V, hDH V, FUBP1|
|Target/Specificity||FUBP1 (AAH17247.1, 1 a.a. ~ 653 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||FUBP1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.
Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR. Hsiao HH, et al. Biochemistry, 2010 Jun 8. PMID 20420426.Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth. Rabenhorst U, et al. Hepatology, 2009 Oct. PMID 19637194.Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells. Malz M, et al. Hepatology, 2009 Oct. PMID 19585652.Far upstream element-binding protein-1, a novel caspase substrate, acts as a cross-talker between apoptosis and the c-myc oncogene. Jang M, et al. Oncogene, 2009 Mar 26. PMID 19219071.Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Martins-de-Souza D, et al. Eur Arch Psychiatry Clin Neurosci, 2009 Apr. PMID 19165527.
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