GEMIN6 Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a full length recombinant GEMIN6.
|Application ||WB, E|
|Calculated MW||18824 Da|
|Other Names||Gem-associated protein 6, Gemin-6, SIP2, GEMIN6|
|Target/Specificity||GEMIN6 (AAH18195, 1 a.a. ~ 167 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GEMIN6 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Svendsen JM, et al. Cell, 2009 Jul 10. PMID 19596235.Gemin8 is required for the architecture and function of the survival motor neuron complex. Carissimi C, et al. J Biol Chem, 2006 Dec 1. PMID 17023415.Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure. Ma Y, et al. Structure, 2005 Jun. PMID 15939020.Unrip is a component of SMN complexes active in snRNP assembly. Carissimi C, et al. FEBS Lett, 2005 Apr 25. PMID 15848170.
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