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GLRA1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant GLRA1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P23415 |
| Other Accession | NM_000171 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2E7 |
| Calculated MW | 52624 Da |
| Gene ID | 2741 |
|---|---|
| Other Names | Glycine receptor subunit alpha-1, Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit, GLRA1 |
| Target/Specificity | GLRA1 (NP_000162, 121 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | GLRA1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.
References
External divalent cations increase anion-cation permeability ratio in glycine receptor channels. Sugiharto S, et al. Pflugers Arch, 2010 Jun. PMID 20198385.Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting. Melzer N, et al. J Biol Chem, 2010 Feb 5. PMID 19959465.Genetical genomic determinants of alcohol consumption in rats and humans. Tabakoff B, et al. BMC Biol, 2009 Oct 27. PMID 19874574.Recessive hyperekplexia mutations of the glycine receptor alpha1 subunit affect cell surface integration and stability. Villmann C, et al. J Neurochem, 2009 Nov. PMID 19732286.Interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: a patch clamp study. Ziegler E, et al. Naunyn Schmiedebergs Arch Pharmacol, 2009 Oct. PMID 19705103.
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