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GLRA1 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant GLRA1.

  • WB - GLRA1 Antibody (monoclonal) (M01) AT2209a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • WB - GLRA1 Antibody (monoclonal) (M01) AT2209a
    Western Blot analysis of GLRA1 expression in transfected 293T cell line by GLRA1 monoclonal antibody (M01), clone 2E6.

    Lane 1: GLRA1 transfected lysate(51.7 KDa).
    Lane 2: Non-transfected lysate.
  • E - GLRA1 Antibody (monoclonal) (M01) AT2209a
    Detection limit for recombinant GST tagged GLRA1 is approximately 3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23415
Other Accession NM_000171
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 2E7
Calculated MW 52624 Da
Additional Information
Gene ID 2741
Other Names Glycine receptor subunit alpha-1, Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit, GLRA1
Target/Specificity GLRA1 (NP_000162, 121 a.a. ~ 220 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsGLRA1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.


External divalent cations increase anion-cation permeability ratio in glycine receptor channels. Sugiharto S, et al. Pflugers Arch, 2010 Jun. PMID 20198385.Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting. Melzer N, et al. J Biol Chem, 2010 Feb 5. PMID 19959465.Genetical genomic determinants of alcohol consumption in rats and humans. Tabakoff B, et al. BMC Biol, 2009 Oct 27. PMID 19874574.Recessive hyperekplexia mutations of the glycine receptor alpha1 subunit affect cell surface integration and stability. Villmann C, et al. J Neurochem, 2009 Nov. PMID 19732286.Interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: a patch clamp study. Ziegler E, et al. Naunyn Schmiedebergs Arch Pharmacol, 2009 Oct. PMID 19705103.

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$ 315.00
Cat# AT2209a
(40 western blots)
Availability: 7-10 days
Bulk Size
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