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GNGT2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant GNGT2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O14610 |
| Other Accession | BC008663 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1G11-C7 |
| Calculated MW | 7747 Da |
| Gene ID | 2793 |
|---|---|
| Other Names | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2, G gamma-C, G-gamma-8, G-gamma-9, Guanine nucleotide binding protein gamma transducing activity polypeptide 2, GNGT2, GNG8, GNG9, GNGT8 |
| Target/Specificity | GNGT2 (AAH08663, 1 a.a. ~ 69 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | GNGT2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. There is evidence for use of multiple polyadenylation sites by this gene.
References
beta-Arrestin1 interacts with the G-protein subunits beta1gamma2 and promotes beta1gamma2-dependent Akt signalling for NF-kappaB activation. Yang M, et al. Biochem J, 2009 Jan 1. PMID 18729826.The molecular basis for T-type Ca2+ channel inhibition by G protein beta2gamma2 subunits. DePuy SD, et al. Proc Natl Acad Sci U S A, 2006 Sep 26. PMID 16973746.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel. Ivanina T, et al. J Biol Chem, 2003 Aug 1. PMID 12743112.Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. Cuello F, et al. J Biol Chem, 2003 Feb 28. PMID 12486123.
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