GPS2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant GPS2.
|Application ||WB, E|
|Calculated MW||36689 Da|
|Other Names||G protein pathway suppressor 2, GPS-2, GPS2|
|Target/Specificity||GPS2 (AAH13652, 228 a.a. ~ 327 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||GPS2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.
1.Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis.Sanyal S, Bavner A, Haroniti A, Nilsson LM, Lundasen T, Rehnmark S, Witt MR, Einarsson C, Talianidis I, Gustafsson JA, Treuter E.Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15665-70. Epub 2007 Sep 25.
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