HDAC1 Antibody (monoclonal) (M14)
Mouse monoclonal antibody raised against a full length recombinant HDAC1.
|Application ||WB, IHC, IF, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||55103 Da|
|Other Names||Histone deacetylase 1, HD1, HDAC1, RPD3L1|
|Target/Specificity||HDAC1 (AAH00301, 1 a.a. ~ 482 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HDAC1 Antibody (monoclonal) (M14) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy. Yang Z, et al. Clin Chem Lab Med, 2010 Aug 24. PMID 20731616.CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1. Leone V, et al. Oncogene, 2010 Jul 29. PMID 20498639.Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1. Kang SA, et al. Biochem Pharmacol, 2010 Sep 15. PMID 20438716.Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Adams H, et al. Expert Opin Ther Targets, 2010 Jun. PMID 20415600.Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha through histone deacetylase 1. Matsuyama R, et al. J Biol Chem, 2010 Jun 11. PMID 20400511.
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