HDAC5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant HDAC5.
|Application ||WB, IF, E|
|Calculated MW||121978 Da|
|Other Names||Histone deacetylase 5, HD5, Antigen NY-CO-9, HDAC5, KIAA0600|
|Target/Specificity||HDAC5 (AAH51824, 330 a.a. ~ 429 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HDAC5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases. Harrison BC, et al. FEBS Lett, 2010 Mar 19. PMID 20188095. Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS. Wang W, et al. Blood, 2010 Apr 8. PMID 20042720. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Rivadeneira F, et al. Nat Genet, 2009 Nov. PMID 19801982.
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