HIC1 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant HIC1.
|Application ||WB, IF, E|
|Calculated MW||76508 Da|
|Other Names||Hypermethylated in cancer 1 protein, Hic-1, Zinc finger and BTB domain-containing protein 29, HIC1, ZBTB29|
|Target/Specificity||HIC1 (NP_006488, 396 a.a. ~ 453 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HIC1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants.
Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer. Pehlivan S, et al. Cancer Genet Cytogenet, 2010 Sep. PMID 20682398.Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells. Van Rechem C, et al. Mol Cell Biol, 2010 Aug. PMID 20547755.A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1. Zhang W, et al. Oncogene, 2010 Apr 29. PMID 20154726.HIC1 regulates tumor cell responses to endocrine therapies. Zhang B, et al. Mol Endocrinol, 2009 Dec. PMID 19819984.
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