HOXD3 Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant HOXD3.
|Application ||WB, IF, E|
|Calculated MW||45730 Da|
|Other Names||Homeobox protein Hox-D3, Homeobox protein Hox-4A, HOXD3, HOX1D, HOX4A|
|Target/Specificity||HOXD3 (NP_008829, 334 a.a. ~ 431 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||HOXD3 Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.
DNA methylation of HOXD3 as a marker of prostate cancer progression. Kron KJ, et al. Lab Invest, 2010 Jul. PMID 20212450.Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. Ester AR, et al. Am J Med Genet A, 2009 Dec. PMID 19938081.High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, et al. J Bone Miner Res, 2009 Dec. PMID 19453261.Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays. Kron K, et al. PLoS One, 2009. PMID 19283074.Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis. Strathdee G, et al. Clin Cancer Res, 2007 Sep 1. PMID 17785556.
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