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IL10 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant IL10.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P22301 |
| Other Accession | NM_000572 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG3 Kappa |
| Clone Names | 1C10 |
| Calculated MW | 20517 Da |
| Gene ID | 3586 |
|---|---|
| Other Names | Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, IL10 |
| Target/Specificity | IL10 (AAI04253.1, 74 a.a. ~ 178 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | IL10 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
References
Association of Interleukin-10 Polymorphisms with Cytokines in Type 2 Diabetic Nephropathy. Kung WJ, et al. Diabetes Technol Ther, 2010 Sep 1. PMID 20809684.Interleukin-10 microsatellite variants and the risk of acute coronary syndrome among Tunisians. Ben-Hadj-Khalifa-Kechiche S, et al. Int J Immunogenet, 2010 Aug 29. PMID 20807264.Intereleukin-10 promoter polymorphism in mild cognitive impairment and in its clinical evolution. Arosio B, et al. Int J Alzheimers Dis, 2010 Jul 20. PMID 20798845.The associations between two polymorphisms in the interleukin-10 gene promoter and breast cancer risk. Yu KD, et al. Breast Cancer Res Treat, 2010 Aug 25. PMID 20737205.Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese. Liu J, et al. BMC Cancer, 2010 Aug 24. PMID 20735825.
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