ING1 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant ING1.
|Application ||WB, E|
|Calculated MW||46738 Da|
|Other Names||Inhibitor of growth protein 1, ING1|
|Target/Specificity||ING1 (NP_937862.1, 41 a.a. ~ 140 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ING1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
The inhibitor of growth 1 (ING1) proteins suppress angiogenesis and differentially regulate angiopoietin expression in glioblastoma cells. Tallen G, et al. Oncol Res, 2009. PMID 20066899.Genetic variation in healthy oldest-old. Halaschek-Wiener J, et al. PLoS One, 2009 Aug 14. PMID 19680556.Nuclear exclusion of p33ING1b tumor suppressor protein: explored in HCC cells using a new highly specific antibody. Sayan B, et al. Hybridoma (Larchmt), 2009 Feb. PMID 19132896.Human inhibitor of growth 1 inhibits hepatoma cell growth and influences p53 stability in a variant-dependent manner. Zhu Z, et al. Hepatology, 2009 Feb. PMID 19085961.Tethering by lamin A stabilizes and targets the ING1 tumour suppressor. Han X, et al. Nat Cell Biol, 2008 Nov. PMID 18836436.
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