IRF4 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant IRF4.
|Application ||WB, IHC, E|
|Calculated MW||51772 Da|
|Other Names||Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5, IRF4, MUM1|
|Target/Specificity||IRF4 (NP_002451, 342 a.a. ~ 451 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||IRF4 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Staudt V, et al. Immunity, 2010 Aug 27. PMID 20674401.Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom. Newton-Bishop JA, et al. Cancer Epidemiol Biomarkers Prev, 2010 Aug. PMID 20647408.IRF4 variants have age-specific effects on nevus count and predispose to melanoma. Duffy DL, et al. Am J Hum Genet, 2010 Jul 9. PMID 20602913.Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. Ucisik-Akkaya E, et al. Mol Hum Reprod, 2010 Oct. PMID 20587610.Web-based, participant-driven studies yield novel genetic associations for common traits. Eriksson N, et al. PLoS Genet, 2010 Jun 24. PMID 20585627.
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