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IRF4 Antibody (monoclonal) (M05)

Mouse monoclonal antibody raised against a partial recombinant IRF4.

     
  • IF - IRF4 Antibody (monoclonal) (M05) AT2545a
    Immunofluorescence of monoclonal antibody to IRF4 on HeLa cell . [antibody concentration 10 ug/ml]
    detail
  • WB - IRF4 Antibody (monoclonal) (M05) AT2545a
    Western blot analysis of IRF4 over-expressed 293 cell line, cotransfected with IRF4 Validated Chimera RNAi ( (Cat # AT2545a )
    detail
  • WB - IRF4 Antibody (monoclonal) (M05) AT2545a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .
    detail
  • WB - IRF4 Antibody (monoclonal) (M05) AT2545a
    Western Blot analysis of IRF4 expression in transfected 293T cell line by IRF4 monoclonal antibody (M05), clone 2D1.

    Lane 1: IRF4 transfected lysate(51.8 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • E - IRF4 Antibody (monoclonal) (M05) AT2545a
    Detection limit for recombinant GST tagged IRF4 is approximately 0.03ng/ml as a capture antibody.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, E
Primary Accession Q15306
Other Accession NM_002460
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2b Kappa
Clone Names 2D1
Calculated MW 51772 Da
Additional Information
Gene ID 3662
Other Names Interferon regulatory factor 4, IRF-4, Lymphocyte-specific interferon regulatory factor, LSIRF, Multiple myeloma oncogene 1, NF-EM5, IRF4, MUM1
Target/Specificity IRF4 (NP_002451, 342 a.a. ~ 451 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsIRF4 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.

References

Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Staudt V, et al. Immunity, 2010 Aug 27. PMID 20674401.Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom. Newton-Bishop JA, et al. Cancer Epidemiol Biomarkers Prev, 2010 Aug. PMID 20647408.IRF4 variants have age-specific effects on nevus count and predispose to melanoma. Duffy DL, et al. Am J Hum Genet, 2010 Jul 9. PMID 20602913.Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. Ucisik-Akkaya E, et al. Mol Hum Reprod, 2010 Oct. PMID 20587610.Web-based, participant-driven studies yield novel genetic associations for common traits. Eriksson N, et al. PLoS Genet, 2010 Jun 24. PMID 20585627.

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$ 350.00
Cat# AT2545a
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Availability: 7-10 days
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