ISL1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant ISL1.
|Application ||WB, IF|
|Calculated MW||39036 Da|
|Other Names||Insulin gene enhancer protein ISL-1, Islet-1, ISL1|
|Target/Specificity||ISL1 (NP_002193, 63 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ISL1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
1.ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex.Zhang Q, Yang Z, Jia Z, Liu C, Guo C, Lu H, Chen P, Ma K, Wang W, Zhou CMol Cancer. 2014 Jul 29;13(1):181. doi: 10.1186/1476-4598-13-181.2.A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic β-cells.Zhang Q, Yang Z, Wang W, Guo T, Jia Z, Ma K, Zhou CBiochem Biophys Res Commun. 2014 Jul 4;449(3):295-300. doi: 10.1016/j.bbrc.2014.05.021. Epub 2014 May 15.3.Interaction of Wnt/?]-catenin and Notch signaling in the early stage of cardiac differentiation of P19CL6 cells.Li B, Jia Z, Wang T, Wang W, Zhang C, Chen P, Ma K, Zhou C.J Cell Biochem. 2011 Sep 28. doi: 10.1002/jcb.23390.4.ISL1 Promotes Pancreatic Islet Cell Proliferation.Guo T, Wang W, Zhang H, Liu Y, Chen P, Ma K, Zhou C.PLoS One. 2011;6(8):e22387. Epub 2011 Aug 4.
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