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ISL1 Antibody (monoclonal) (M05)

Mouse monoclonal antibody raised against a partial recombinant ISL1.

  • WB - ISL1 Antibody (monoclonal) (M05) AT2561a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.41 KDa) .
  • WB - ISL1 Antibody (monoclonal) (M05) AT2561a
    ISL1 monoclonal antibody (M05), clone 2E7 Western Blot analysis of ISL1 expression in PC-12 ( (Cat # AT2561a )
  • IF - ISL1 Antibody (monoclonal) (M05) AT2561a
    Immunofluorescence of monoclonal antibody to ISL1 on HeLa cell. [antibody concentration 10 ug/ml]
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61371
Other Accession NM_002202
Reactivity Human, Rat
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 2E8
Calculated MW 39036 Da
Additional Information
Gene ID 3670
Other Names Insulin gene enhancer protein ISL-1, Islet-1, ISL1
Target/Specificity ISL1 (NP_002193, 63 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsISL1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.


1.ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex.Zhang Q, Yang Z, Jia Z, Liu C, Guo C, Lu H, Chen P, Ma K, Wang W, Zhou CMol Cancer. 2014 Jul 29;13(1):181. doi: 10.1186/1476-4598-13-181.2.A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic β-cells.Zhang Q, Yang Z, Wang W, Guo T, Jia Z, Ma K, Zhou CBiochem Biophys Res Commun. 2014 Jul 4;449(3):295-300. doi: 10.1016/j.bbrc.2014.05.021. Epub 2014 May 15.3.Interaction of Wnt/?]-catenin and Notch signaling in the early stage of cardiac differentiation of P19CL6 cells.Li B, Jia Z, Wang T, Wang W, Zhang C, Chen P, Ma K, Zhou C.J Cell Biochem. 2011 Sep 28. doi: 10.1002/jcb.23390.4.ISL1 Promotes Pancreatic Islet Cell Proliferation.Guo T, Wang W, Zhang H, Liu Y, Chen P, Ma K, Zhou C.PLoS One. 2011;6(8):e22387. Epub 2011 Aug 4.

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$ 315.00
Cat# AT2561a
(40 western blots)
Availability: 7-10 days
Bulk Size
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