ITGB7 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant ITGB7.
|Calculated MW||86903 Da|
|Other Names||Integrin beta-7, Gut homing receptor beta subunit, ITGB7|
|Target/Specificity||ITGB7 (NP_000880, 401 a.a. ~ 505 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ITGB7 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1. Cicala C, et al. Proc Natl Acad Sci U S A, 2009 Dec 8. PMID 19933330.The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin. Pentik?inen U, et al. J Mol Biol, 2009 Oct 30. PMID 19699211.Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. Lad Y, et al. J Biol Chem, 2008 Dec 12. PMID 18829455.AhR- and c-maf-dependent induction of beta7-integrin expression in human macrophages in response to environmental polycyclic aromatic hydrocarbons. Monteiro P, et al. Biochem Biophys Res Commun, 2007 Jun 29. PMID 17490615.Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. Le Floc'h A, et al. J Exp Med, 2007 Mar 19. PMID 17325197.
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