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KCNE1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant KCNE1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P15382 |
| Other Accession | NM_000219 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5B12 |
| Calculated MW | 14675 Da |
| Gene ID | 3753 |
|---|---|
| Other Names | Potassium voltage-gated channel subfamily E member 1, Delayed rectifier potassium channel subunit IsK, IKs producing slow voltage-gated potassium channel subunit beta Mink, Minimal potassium channel, KCNE1 |
| Target/Specificity | KCNE1 (NP_000210, 67 a.a. ~ 129 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KCNE1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.
References
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Causes of hearing impairment in the Norwegian paediatric cochlear implant program. Siem G, et al. Int J Audiol, 2010 Aug. PMID 20553101.Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1. Lvov A, et al. J Gen Physiol, 2010 Jun. PMID 20479109.L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. Yokoyama K, et al. Nephron Clin Pract, 2010. PMID 20424473.Common variants in cardiac ion channel genes are associated with sudden cardiac death. Albert CM, et al. Circ Arrhythm Electrophysiol, 2010 Jun 1. PMID 20400777.
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