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KCNK10 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant KCNK10.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P57789 |
| Other Accession | NM_021161 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1C1 |
| Calculated MW | 59765 Da |
| Gene ID | 54207 |
|---|---|
| Other Names | Potassium channel subfamily K member 10, Outward rectifying potassium channel protein TREK-2, TREK-2 K(+) channel subunit, KCNK10, TREK2 |
| Target/Specificity | KCNK10 (NP_066984, 439 a.a. ~ 538 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | KCNK10 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
References
Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. Gierten J, et al. Br J Pharmacol, 2008 Aug. PMID 18516069.Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment. Huang D, et al. Med Hypotheses, 2008. PMID 17689202.International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. Goldstein SA, et al. Pharmacol Rev, 2005 Dec. PMID 16382106.Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. Gu W, et al. J Physiol, 2002 Mar 15. PMID 11897838.
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