KISS1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant KISS1.
|Application ||WB, IHC, E|
|Calculated MW||14705 Da|
|Other Names||Metastasis-suppressor KiSS-1, Kisspeptin-1, Metastin, Kisspeptin-54, Kisspeptin-14, Kisspeptin-13, Kisspeptin-10, KISS1|
|Target/Specificity||KISS1 (NP_002247, 46 a.a. ~ 145 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||KISS1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may function to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
1.Menstrual cyclic change of metastin/GPR54 in endometrium.Baba T, Kang HS, Hosoe Y, Kharma B, Abiko K, Matsumura N, Hamanishi J, Yamaguchi K, Yoshioka Y, Koshiyama M, Mandai M, Murphy SK, Konishi IMed Mol Morphol. 2014 Jun 8.2.Determination of KISS1, KISS1R and Kisspeptin in Fat Tissue of Normal Weight and Obese Humans and Correlations between Serum Kisspeptin and Leptin.Sitticharoon C, Boonpuan V, Mitrpant C, Churintaraphan M.Siriraj Med J 2013;65: 112-1163.Expression of KiSS-1 in Epithelial Ovarian Cancer and its Role in Metastasis.Zhu W, Gao A, Chen X, Li F, Nan J, Zhang H.Applied Mechanics and Materials Vol. 140 (2012) pp 142-1514.GPR54 is a target for suppression of metastasis in endometrial cancer.Kang HS, Baba T, Mandai M, Matsumura N, Hamanishi J, Kharma B, Kondoh E, Yoshioka Y, Oishi S, Fujii N, Murphy SK, Konishi I.Mol Cancer Ther. 2011 Jan 31. [Epub ahead of print]5.Expression of the metastasis suppressor gene KISS1 in uveal melanoma.Martins CM, Fernandes BF, Antecka E, Di Cesare S, Mansure JJ, Marshall JC, Burnier MN Jr.Eye. 2008 May;22(5):707-11. Epub 2008 Jan 25.
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