KRT18 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full length recombinant KRT18.
|Application ||WB, IF, E|
|Calculated MW||48058 Da|
|Other Names||Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18|
|Target/Specificity||KRT18 (AAH20982, 1 a.a. ~ 430 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||KRT18 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
Ectopic coexpression of keratin 8 and 18 promotes invasion of transformed keratinocytes and is induced in patients with cutaneous squamous cell carcinoma. Yamashiro Y, et al. Biochem Biophys Res Commun, 2010 Aug 27. PMID 20659422.Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations. Strnad P, et al. Gastroenterology, 2010 Sep. PMID 20538000.Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. Nagashio R, et al. Pathol Int, 2010 Feb. PMID 20398190.Relationship between serum concentrations of keratin-18 and apoptosis in chronic hepatitis C. Gonzalez-Quintela A, et al. Clin Chem Lab Med, 2010 Jun. PMID 20374042.
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