LASS6 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant LASS6.
|Application ||WB, IHC, E|
|Calculated MW||44890 Da|
|Other Names||Ceramide synthase 6, CerS6, LAG1 longevity assurance homolog 6, CERS6, LASS6|
|Target/Specificity||LASS6 (NP_982288, 62 a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||LASS6 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1.Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.Jensen SA, Calvert AE, Volpert G, Kouri FM, Hurley LA, Luciano JP, Wu Y, Chalastanis A, Futerman AH, Stegh AHProc Natl Acad Sci U S A. 2014 Apr 15;111(15):5682-7. doi: 10.1073/pnas.1316700111. Epub 2014 Mar 31.2.Modulation of ceramide synthase activity via dimerization.Laviad EL, Kelly S, Merrill AH Jr, Futerman AH.J Biol Chem. 2012 Apr 26.3.D,l-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein expression in A549 cells.Yamane M, Miyazawa K, Moriya S, Abe A, Yamane S.Biochimie. 2011 May 7. [Epub ahead of print]4.Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R.Cell Signal. 2010 Apr 18. [Epub ahead of print]5.Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.Ruckhaberle E, Holtrich U, Engels K, Hanker L, Gatje R, Metzler D, Karn T, Kaufmann M, Rody A.Climacteric. 2009 Jul 31:1-12. [Epub ahead of print]
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