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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LEP Antibody (monoclonal) (M02)   

LEP Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a full length recombinant LEP.

  • E - LEP Antibody (monoclonal) (M02) AT2695a
    Detection limit for recombinant GST tagged LEP is approximately 0.1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P41159
Other Accession BC060830
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names M1
Calculated MW 18641 Da
Additional Information
Gene ID 3952
Other Names Leptin, Obese protein, Obesity factor, LEP, OB, OBS
Target/Specificity LEP (AAH60830.1, 22 a.a. ~ 167 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsLEP Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.


Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Sarzynski MA, et al. Int J Obes (Lond), 2010 Aug 24. PMID 20733583.A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868.Association of the leptin gene with knee osteoarthritis susceptibility in a Han Chinese population: a case-control study. Qin J, et al. J Hum Genet, 2010 Jul 22. PMID 20664554.Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. Friedlander Y, et al. Ann Hum Genet, 2010 Sep 1. PMID 20642810.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.

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$ 315.00
Cat# AT2695a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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