MAPRE2 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant MAPRE2.
|Application ||WB, IHC, IF|
|Calculated MW||37031 Da|
|Other Names||Microtubule-associated protein RP/EB family member 2, APC-binding protein EB2, End-binding protein 2, EB2, MAPRE2, RP1|
|Target/Specificity||MAPRE2 (NP_055083, 1 a.a. ~ 62 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||MAPRE2 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR. Alternative splicing results in multiple transcript variants.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Molecular insights into mammalian end-binding protein heterodimerization. De Groot CO, et al. J Biol Chem, 2010 Feb 19. PMID 20008324.The microtubule-associated protein MAPRE2 is involved in perineural invasion of pancreatic cancer cells. Abiatari I, et al. Int J Oncol, 2009 Nov. PMID 19787265.Interactions between EB1 and microtubules: dramatic effect of affinity tags and evidence for cooperative behavior. Zhu ZC, et al. J Biol Chem, 2009 Nov 20. PMID 19778897.Suppression of microtubule dynamic instability by the +TIP protein EB1 and its modulation by the CAP-Gly domain of p150glued. Manna T, et al. Biochemistry, 2008 Jan 15. PMID 18081319.
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