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MLH1 Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a full length recombinant MLH1.

  • WB - MLH1 Antibody (monoclonal) (M02) AT2879a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (108.9 KDa) .
  • WB - MLH1 Antibody (monoclonal) (M02) AT2879a
    MLH1 monoclonal antibody (M02), clone M1 Western Blot analysis of MLH1 expression in Hela S3 NE ( (Cat # AT2879a )
  • IHC - MLH1 Antibody (monoclonal) (M02) AT2879a
    Immunoperoxidase of monoclonal antibody to MLH1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 1 ug/ml]
  • IF - MLH1 Antibody (monoclonal) (M02) AT2879a
    Immunofluorescence of monoclonal antibody to MLH1 on HeLa cell. [antibody concentration 10 ug/ml]
  • E - MLH1 Antibody (monoclonal) (M02) AT2879a
    Detection limit for recombinant GST tagged MLH1 is approximately 0.03ng/ml as a capture antibody.
  •  - MLH1 Antibody (monoclonal) (M02) AT2879a
    Proximity Ligation Analysis of protein-protein interactions between MSH2 and MLH1 HeLa cells were stained with anti-MSH2 rabbit purified polyclonal 1:1200 and anti-MLH1 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P40692
Other Accession BC006850
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names M1
Calculated MW 84601 Da
Additional Information
Gene ID 4292
Other Names DNA mismatch repair protein Mlh1, MutL protein homolog 1, MLH1, COCA2
Target/Specificity MLH1 (AAH06850, 1 a.a. ~ 756 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsMLH1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.


Association between Genetic Polymorphisms in the XRCC1, XRCC3, XPD, GSTM1, GSTT1, MSH2, MLH1, MSH3, and MGMT Genes and Radiosensitivity in Breast Cancer Patients. Mangoni M, et al. Int J Radiat Oncol Biol Phys, 2010 Aug 11. PMID 20708344.A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. Ho-Pun-Cheung A, et al. Pharmacogenomics J, 2010 Jul 20. PMID 20644561.Lynch syndrome: the influence of environmental factors on extracolonic cancer risk in hMLH1 c.C1528T mutation carriers and their mutation-negative sisters. Blokhuis MM, et al. Fam Cancer, 2010 Sep. PMID 20640520.Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers. van der Post RS, et al. J Med Genet, 2010 Jul. PMID 20591884.Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Monsees GM, et al. Breast Cancer Res Treat, 2010 May 23. PMID 20496165.

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$ 315.00
Cat# AT2879a
(40 western blots)
Availability: 7-10 days
Bulk Size
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