MPZ Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a full length recombinant MPZ.
|Calculated MW||27555 Da|
|Other Names||Myelin protein P0, Myelin peripheral protein, MPP, Myelin protein zero, MPZ|
|Target/Specificity||MPZ (AAH06491.1, 1 a.a. ~ 258 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||MPZ Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a major structural protein of peripheral myelin. Mutations in this gene result in the autosomal dominant form of Charcot-Marie-Tooth disease type 1 and other polyneuropathies.
Charcot-Marie-Tooth disease with intermediate conduction velocities caused by a novel mutation in the MPZ gene. Banchs I, et al. Muscle Nerve, 2010 Aug. PMID 20544920.Charcot-Marie-Tooth disease due to novel myelin protein zero mutation presenting as late-onset remitting sensory neuropathy. Simpson BS, et al. J Clin Neuromuscul Dis, 2010 Jun. PMID 20516806.Asymmetric phenotype associated with rare myelin protein zero mutation. Souayah N, et al. J Clin Neuromuscul Dis, 2010 Mar. PMID 20215982.Laryngeal neuropathy of Charcot-Marie-Tooth disease: further observations and novel mutations associated with vocal fold paresis. Benson B, et al. Laryngoscope, 2010 Feb. PMID 19950375.[Predominant parasympathetic involvement in a patient with Charcot-Marie-Tooth disease caused by the MPZ Thr124Met mutation] Nakamura N, et al. Rinsho Shinkeigaku, 2009 Sep. PMID 19928689.
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