MPZ Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a full length recombinant MPZ.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
---|---|
Primary Accession | P25189 |
Other Accession | BC006491 |
Reactivity | Human |
Host | mouse |
Clonality | Monoclonal |
Isotype | IgG2a Kappa |
Clone Names | 3B12 |
Calculated MW | 27555 Da |
Gene ID | 4359 |
---|---|
Other Names | Myelin protein P0, Myelin peripheral protein, MPP, Myelin protein zero, MPZ |
Target/Specificity | MPZ (AAH06491.1, 1 a.a. ~ 258 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | MPZ Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a major structural protein of peripheral myelin. Mutations in this gene result in the autosomal dominant form of Charcot-Marie-Tooth disease type 1 and other polyneuropathies.
References
Charcot-Marie-Tooth disease with intermediate conduction velocities caused by a novel mutation in the MPZ gene. Banchs I, et al. Muscle Nerve, 2010 Aug. PMID 20544920.Charcot-Marie-Tooth disease due to novel myelin protein zero mutation presenting as late-onset remitting sensory neuropathy. Simpson BS, et al. J Clin Neuromuscul Dis, 2010 Jun. PMID 20516806.Asymmetric phenotype associated with rare myelin protein zero mutation. Souayah N, et al. J Clin Neuromuscul Dis, 2010 Mar. PMID 20215982.Laryngeal neuropathy of Charcot-Marie-Tooth disease: further observations and novel mutations associated with vocal fold paresis. Benson B, et al. Laryngoscope, 2010 Feb. PMID 19950375.[Predominant parasympathetic involvement in a patient with Charcot-Marie-Tooth disease caused by the MPZ Thr124Met mutation] Nakamura N, et al. Rinsho Shinkeigaku, 2009 Sep. PMID 19928689.
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