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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   NBN Antibody (monoclonal) (M01)   

NBN Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant NBN.

  • WB - NBN Antibody (monoclonal) (M01) AT2976a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .
  • WB - NBN Antibody (monoclonal) (M01) AT2976a
    NBN monoclonal antibody (M01), clone 3E4 Western Blot analysis of NBN expression in COLO 320 HSR ( (Cat # AT2976a )
  • WB - NBN Antibody (monoclonal) (M01) AT2976a
    NBN monoclonal antibody (M01), clone 3E4 Western Blot analysis of NBN expression in HL-60 ( (Cat # AT2976a )
  • E - NBN Antibody (monoclonal) (M01) AT2976a
    Detection limit for recombinant GST tagged NBN is approximately 3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60934
Other Accession NM_002485
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 3E5
Calculated MW 84959 Da
Additional Information
Gene ID 4683
Other Names Nibrin, Cell cycle regulatory protein p95, Nijmegen breakage syndrome protein 1, NBN, NBS, NBS1, P95
Target/Specificity NBN (NP_002476, 645 a.a. ~ 754 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsNBN Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.


Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population. Jelonek K, et al. J Appl Genet, 2010. PMID 20720310.A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. Ho-Pun-Cheung A, et al. Pharmacogenomics J, 2010 Jul 20. PMID 20644561.Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.Gamma-Radiation Sensitivity and Polymorphisms in RAD51L1 Modulate Glioma Risk. Liu Y, et al. Carcinogenesis, 2010 Jul 7. PMID 20610542.The NBS1 genetic polymorphisms and the risk of the systemic lupus erythematosus in Taiwanese patients. Lin YJ, et al. J Clin Immunol, 2010 Sep. PMID 20571895.

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$ 315.00
Cat# AT2976a
(40 western blots)
Availability: 7-10 days
Bulk Size
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