NFYC Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant NFYC.
|Application ||WB, IHC, IF, E|
|Calculated MW||50302 Da|
|Other Names||Nuclear transcription factor Y subunit gamma, CAAT box DNA-binding protein subunit C, Nuclear transcription factor Y subunit C, NF-YC, Transactivator HSM-1/2, NFYC|
|Target/Specificity||NFYC (AAH05003, 14 a.a. ~ 113 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||NFYC Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.
Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. Ichikawa S, et al. J Bone Miner Res, 2010 Aug. PMID 20200978.NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor. Murai-Takeda A, et al. J Biol Chem, 2010 Mar 12. PMID 20054001.NF-YC complexity is generated by dual promoters and alternative splicing. Ceribelli M, et al. J Biol Chem, 2009 Dec 4. PMID 19690168.Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple cancers. Yamanaka K, et al. Genomics, 2009 Oct. PMID 19559782.Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Horikawa Y, et al. Clin Cancer Res, 2008 Dec 1. PMID 19047128.
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