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NKX3-1 Antibody (monoclonal) (M02)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT3058a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
NKX3-1 Antibody (monoclonal) (M02) - Product info | |
| Application | IF, WB
|
| Primary Accession | Q99801 |
| Other Accession | NP_006158 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 1C7 |
| Calculated MW | 26350 Da |
NKX3-1 Antibody (monoclonal) (M02) - Additional info | |
| Gene ID 4824 | |
| Other Names NKX3.1, NKX3ANK3 transcription factor related, locus 1 (Drosophila) | |
| Target/Specificity NKX3-1 (NP_006158, 100 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions NKX3-1 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. | |
NKX3-1 Antibody (monoclonal) (M02) - Related products
AP8996c: NKX3-1 Antibody (Center)
RI13600: NKX3-1 predesign siRNA
BP8996c: NKX3-1 Antibody (Center) Blocking Peptide
NKX3-1 Antibody (monoclonal) (M02) - Application data
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Immunofluorescence of monoclonal antibody to NKX3-1 (AT3058a) on NIH/3T3 cell . [antibody concentration 10 ug/ml]
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NKX3-1 monoclonal antibody (M02), clone 1C7 Western Blot analysis of NKX3-1 expression in NIH/3T3 ( Cat # L018V1 ).
NKX3-1 Antibody (monoclonal) (M02) - Research Areas
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BACKGROUND
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.
REFERENCES
NKX3.1 as a marker of prostatic origin in metastatic tumors. Gurel B, et al. Am J Surg Pathol, 2010 Aug. PMID 20588175.Prostate cancer risk-associated variants reported from genome-wide association studies: Meta-analysis and their contribution to genetic Variation. Kim ST, et al. Prostate, 2010 Jun 16. PMID 20564319.ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. Kunderfranco P, et al. PLoS One, 2010 May 10. PMID 20479932.NKX3.1 activates cellular response to DNA damage. Bowen C, et al. Cancer Res, 2010 Apr 15. PMID 20395202.Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region. Thomas MA, et al. Biochem J, 2010 Jan 15. PMID 19886863.
