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NR1D2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant NR1D2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF |
|---|---|
| Primary Accession | Q14995 |
| Other Accession | BC045613 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1G2 |
| Calculated MW | 64643 Da |
| Gene ID | 9975 |
|---|---|
| Other Names | Nuclear receptor subfamily 1 group D member 2, Orphan nuclear hormone receptor BD73, Rev-erb alpha-related receptor, RVR, Rev-erb-beta, V-erbA-related protein 1-related, EAR-1R, NR1D2 |
| Target/Specificity | NR1D2 (AAH45613, 1 a.a. ~ 579 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | NR1D2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.
References
Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder. Campos-de-Sousa S, et al. J Biol Rhythms, 2010 Apr. PMID 20348464.Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. Liu AC, et al. PLoS Genet, 2008 Feb 29. PMID 18454201.Nuclear hormone receptors for heme: REV-ERBalpha and REV-ERBbeta are ligand-regulated components of the mammalian clock. Burris TP. Mol Endocrinol, 2008 Jul. PMID 18218725.Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Raghuram S, et al. Nat Struct Mol Biol, 2007 Dec. PMID 18037887.The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter. Wang J, et al. Biochim Biophys Acta, 2008 Feb. PMID 17996965.
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