NUDC Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant NUDC.
|Application ||WB, IF, E|
|Calculated MW||38243 Da|
|Other Names||Nuclear migration protein nudC, Nuclear distribution protein C homolog, NUDC|
|Target/Specificity||NUDC (AAH02399, 1 a.a. ~ 331 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||NUDC Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
NudC was first identified as a regulator of nuclear movement in the asexual reproductive cycle of the filamentous fungus Aspergillus nidulans. Human NUDC is a nuclear movement protein that associates with dynein (see DYNC1H1; MIM 600112) (Aumais et al., 2003 [PubMed 12679384]).
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.Interference RNA (RNAi)-based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation. Pang SF, et al. Exp Cell Res, 2009 Dec 10. PMID 19560457.hNUDC promotes the cell proliferation and differentiation in a leukemic cell line via activation of the thrombopoietin receptor (Mpl). Tang YS, et al. Leukemia, 2008 May. PMID 18288130.Regulation of cell differentiation by hNUDC via a Mpl-dependent mechanism in NIH 3T3 cells. Zhang YP, et al. Exp Cell Res, 2007 Sep 10. PMID 17658515.Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
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